Personally my favorite are psychedelics, marijuana(it is officially classified as one and you can definately trip off of it if you take it orally) and DXM(i personally include dissasosiative's with the more traditional phens/tryps/empaths classes of psychedelics, though the trip is alot more internal, obviously, it can be just as if not stronger then the classic psychs)included. DXM and Marijuana is my all time favorite experience, as it really makes the former much more psychedelic.
As for the saftey of such drugs, yes, OTC/legal highs in general are more dangerous then thier illegal counterparts. DXM is somewhere in the middle of Ketamine and PCP in this regard, harder on the body then other psychedelics, but not as bad as some have implied here. It's recently been suggested to actually have neuroprotective properties. Most, if not all, negative effects on the body come from the mass amounts of syrup/inactives people take in unpure forms of dosing. The rest I'd argue probably isn't even as bad for you as a night of heavy drinking. There have been no evidence of any kind of damage to any part of the body with even years of heavy dosing of the drug. Even more recently the theory of onley's legions(NAN) in rats was proven to be false.
Beyond all that the experience itself is much more enjoyable as a psychedelic experience, that I view as mostly internal, aided by meditation anyway. DXM does all the hard work with meditation for you(and yes, I-doser works incredibly well on it), disconnecting you from body, mind and most thought. It's much easier to get a true psychedelic experience(at least IMO) on dxm then others. And yes, I've tried both LSD(and lsa) and mushrooms, and although I'm unsure if I took enough to fully reach the point that is required for a full on psychedelic experience(i did with shrooms once for sure, but also ended up adding some DXM and Pot on top of it lol, so it probably wasn't an accurate perception of the true shroom experience) I still found DXM to be more powerful and intense in that regard(not that the other drugs weren't enjoyable in thier own way or anything, as said that class is considered my favorite, i just include pot and dxm in it as well).
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http://www.theneurologist.org/pt/re/neu ... 28!8091!-1)
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http://www.ncbi.nlm.nih.gov/sites/entre ... d_RVDocSum)
If anyone has any info providing any information at all that even implies that DXM causes any damage to any part of the body/brain, I'd love to see it, as if you couldn't tell I am a frequent user.
On the topic of benadryl, it is indeed alot more dangerous then other OTC and illegal drugs, both mentally and physically. At recreational doses(much like it's counterparts, datura, cpm, belladonna, ect) it is actually quite toxic, and most people can feel this very well. It dries you out horribly, causes joint and muscle pain, aches all throughout your body, racing heart, trouble breathing, ect. Coupled with the actual "trip" itself, which as said isn't really a trip in the normal sense but a semblance to a fever delerium(it is a deleriant after all)this makes these negative feelings all the worse, and at times(dose dependant) you might not actually remember you took a drug at all. It is not uncommon for people to have entire conversations with people that aren't there without realizing it, or leave thier house and/or get into dangerous situations if the delusions become negative/paranoid(spiders/bugs crawling on/under the skin seem fairly common). I don't have sources for this but I'd also guess it is just as likley as other psychedelics(if not more so since most experiences tend to be negative) to cause psychotic breaks and/or trigger underlying mental disorders, I do know anectodally more people report HPPD after diph/dimen trips then all other psychedelics combined. Not that any drug use is recommended, but usually deleriant use is frowned upon as not worth it even within OTC (dxm mainly, for the one I am in) communities, right up there with huffing volatile inhalants.