Depends on the headphones your using. Honestly I say no if you have good headphones just to avoid ruining headphones. I personally would go with Loudness, Small Speaker, Treble Reducer. Those are going to give you a richer sound on crappy headphones which may actually give you the edge.
Rule of thumb: Don't use any software or hardware based enhancement, surround, or boost effects. Doses are engineered to be listened to without addition pre or post processing effects.